Currently on Nplate ®?
If you are currently on Nplate®, then you may be aware of its benefits and risks and how it is different from traditional treatment options.
Durable platelet response
In the two 6-month trials, the primary goal of treatment with Nplate® was "durable platelet response." This was defined as keeping platelet counts greater than or equal to 50,000 per microliter for at least 6 of the last 8 weeks of the 6-month study, even after other ITP treatments were adjusted or taken away. Also, those patients who received rescue therapies at any time during the 6-month trial could not be considered as having a durable platelet response. Studying Nplate® this way helped show how well Nplate® worked by taking the effects of other ITP medications into account.1,2 In the two trials:
- 61% (25/41) of Nplate® patients who did not have a splenectomy met the durable platelet response, versus 5% (1/21) of placebo patients.1,2
- 38% (16/42) of Nplate® patients who have had a splenectomy met the durable platelet response, versus 0% (0/21) of placebo patients.1,2
In the trials, if a patient in any given week had a platelet count of 50,000 per
microliter or greater, that was called a "weekly platelet response." Platelet counts within 8 weeks of rescue medication were not included. If a patient had four or more weekly platelet responses, that patient was considered to have a "transient platelet response."
All the patients who had transient platelet responses and durable platelet responses were added together to obtain the "overall platelet response"1:
- 88% (36/41) of Nplate® patients, versus 14% (3/21) of placebo patients who did not have a splenectomy
had an overall platelet response.1,2
- 79% (33/42) of Nplate® patients, versus 0% (0/21) of placebo patients who had a splenectomy had an
overall platelet response.1,2
It's important to remember that no other treatment has been studied this way. Discuss with your doctor the risks and benefits of staying on weekly Nplate® therapy. Individual patient results may vary.
You should talk to your healthcare provider about any questions or concerns you have about your disease or your treatment.
Learn more about Nplate® and ITP
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