INDICATIONS

Nplate® is a prescription medicine used to treat low blood platelet counts (thrombocytopenia) in:

  • adults with immune thrombocytopenia (ITP) when certain medicines or surgery to remove your spleen have not worked well enough. Read More
  • children 1 year of age and older with ITP for at least 6 months when certain medicines or surgery to remove your spleen have not worked well enough.
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Frequently Asked Questions about Nplate® (romiplostim)

What is Nplate®?

Nplate® is a treatment for low platelet counts in adults and children with immune thrombocytopenia (ITP) when other treatments or medicines have not worked well enough.

LEARN MORE ABOUT HOW NPLATE® CAN HELP

How could Nplate® help adults with ITP?

  • Once-weekly Nplate® has been proven to boost and sustain platelets to lower the risk of bleeding
  • In a study, the majority of adults were able to keep their platelet counts above 50,000 for at least 11 out of the 12 months they were studied

    • — Some of these people were able to stop their ITP treatment with Nplate® and still keep their platelet counts up, called treatment-free remission

    learn more about platelet stability and remission with Nplate®

How could Nplate® help children with ITP?

Studies have shown that 7 out of 10 children (n=30/42) treated with Nplate® were able to raise their platelet levels to 50,000 or higher.

Learn more about Nplate® for children

What can I expect with Nplate®?

Nplate® is a shot (injection) given by your doctor or nurse once a week. Nplate® has no dietary restrictions and no known drug interactions. This means you won't have to change your meal schedule or other medicines.

LEARN MORE ABOUT TAKING Nplate®

What is the most important information I should know about Nplate®?

Nplate® can cause serious side effects, including:

  • Worsening of a precancerous blood condition to a blood cancer (leukemia). Nplate® is not for use in people with a precancerous condition called myelodysplastic syndromes (MDS), or for any condition other than immune thrombocytopenia (ITP). If you have MDS and receive Nplate®, your MDS condition may worsen and become an acute leukemia. If MDS worsens to become acute leukemia you may die sooner from the acute leukemia.
  • Higher risk for blood clots.
    • — You may have a higher risk of getting a blood clot if your platelet count becomes high during treatment with Nplate®. You may have severe complications or die from some forms of blood clots, such as clots that spread to the lungs or that cause heart attacks or strokes.
    • — If you have a chronic liver disease, you may get blood clots in the veins of your liver. This may affect your liver function.
  • Injection of too much Nplate® may cause a dangerous increase in your blood platelet count and serious side effects.
    Your healthcare provider may change your dose or stop Nplate® depending upon the change in your blood platelet count. You must have blood platelet counts done before you start, during, and after Nplate® therapy is stopped.

See What are the possible side effects of Nplate®? for other side effects of Nplate®.

What are the possible side effects of Nplate®?

Nplate® can cause serious side effects.

The most common side effects of Nplate® in adults include:

  • headache
  • joint pain
  • dizziness
  • trouble sleeping
  • muscle tenderness or weakness
  • pain in the arms and legs
  • stomach (abdomen) pain
  • shoulder pain
  • indigestion
  • tingling or numbness in hands and feet
  • bronchitis
  • inflammation of the sinuses (sinusitis)
  • vomiting
  • diarrhea
  • upper respiratory tract infection
  • cough
  • nausea
  • pain in mouth and throat (oropharyngeal pain)
LEARN MORE ABOUT NPLATE® FOR adults

The most common side effects of Nplate® in children 1 year of age and older include:

  • bruising
  • upper respiratory tract infection
  • pain in mouth and throat (oropharyngeal pain)
LEARN MORE ABOUT NPLATE® FOR children

How do I get my Nplate® shot when I'm out of town?

When you're away from your regular doctor or nurse who gives you your Nplate® shot, the ITP Specialist Finder can help you locate a healthcare professional that can administer Nplate®.

learn more

Is there information on long-term safety for Nplate®?

The long-term safety data for Nplate® illustrated that side effects did not increase in frequency with longer drug exposure. The study looked at some patients from previous Nplate® studies. Other safety data can be found in the Prescribing Information and the Important Safety Information.

LEARN MORE ABOUT SIDE EFFECTS WITH NPLATE® IN ADULTS

CAN I GET HELP PAYING FOR THE COST OF NPLATE®?

Whatever type of insurance you have–even if you have none–Nplate® Navigator can help you understand how the cost of your Nplate® medicine may be covered, and refer you to programs that may be able to help you afford it, such as Amgen FIRST STEP™.

What support is available for people taking Nplate®?

If you’ve been prescribed Nplate®, you might have questions about your medicine, how it may be covered by your insurance, or resources within your community. That’s why we created Nplate® Navigator—so you have a single place to go to find the support, tools, and resources* most important to you.

*Resources include referrals to independent nonprofit patient assistance programs. Eligibility for resources provided by independent nonprofit patient assistance programs is based on the nonprofits’ criteria. Amgen has no control over these programs and provides referrals as a courtesy only.

Call 1-888-4ASSIST (1-888-427-7478) to speak to an Amgen Nurse Navigator.

learn more about other resources that may be able to help you

DON'T SEE YOUR QUESTION HERE? ASK YOUR HEALTHCARE TEAM

Important Safety Information

What is the most important information I should know about Nplate®?

  • Nplate® can cause serious side effects, including:

  • Worsening of a precancerous blood condition to a blood cancer (leukemia): Nplate® is not for use in people with a precancerous condition called myelodysplastic syndromes (MDS), or for any condition other than immune thrombocytopenia (ITP). If you have MDS and receive Nplate®, your MDS condition may worsen and become an acute leukemia. If MDS worsens to become acute leukemia you may die sooner from the acute leukemia.

  • Higher risk for blood clots:

    • You may have a higher risk of getting a blood clot if your platelet count becomes high during treatment with Nplate®. You may have severe complications or die from some forms of blood clots, such as clots that spread to the lungs or that cause heart attacks or strokes.
    • If you have a chronic liver disease, you may get blood clots in the veins of your liver. This may affect your liver function.

  • What are the possible side effects of Nplate®?

    • Nplate® may cause serious side effects. See “What is the most important information I should know about Nplate®?”
    • The most common side effects of Nplate® in adults include:
      • headache
      • joint pain
      • dizziness
      • trouble sleeping
      • muscle tenderness or weakness
      • pain in arms and legs
      • stomach (abdomen) pain
      • shoulder pain
      • indigestion
      • tingling or numbness in hands and feet
      • bronchitis
      • inflammation of the sinuses (sinusitis)
      • vomiting
      • diarrhea
      • upper respiratory tract infection
      • cough
      • nausea
      • pain in mouth and throat (oropharyngeal pain)
    • The most common side effects of Nplate® in children 1 year of age and older include:
      • bruising
      • upper respiratory tract infection
      • pain in mouth and throat (oropharyngeal pain)
      • headache
    • People who take Nplate® may have an increased risk of developing new or worsening changes in the bone marrow called “increased reticulin.” These changes may improve if you stop taking Nplate®. Your healthcare provider may need to check your bone marrow for this problem during treatment with Nplate®.
    • These are not all the possible side effects of Nplate®. Tell your healthcare provider if you have any side effect that bothers you or that does not go away. For more information, ask your healthcare provider or pharmacist.
    • If you have any questions about this information, be sure to discuss with your doctor. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

How will I receive Nplate®?

Nplate® is given as an injection under the skin (subcutaneous) one time each week by your healthcare provider. Your healthcare provider will check your platelet count every week and change your dose of Nplate® as needed. This will continue until your healthcare provider decides that your dose of Nplate® can stay the same. After that, you will need to get blood tests every month. When you stop receiving Nplate®, you will need blood tests for at least 2 weeks to check if your platelet count drops too low.

APPROVED USES

Nplate® is a prescription medicine used to treat low blood platelet counts (thrombocytopenia) in:

  • adults with immune thrombocytopenia (ITP) when certain medicines or surgery to remove your spleen have not worked well enough.
  • children 1 year of age and older with ITP for at least 6 months when certain medicines or surgery to remove your spleen have not worked well enough.

Nplate® is not for use in people with a precancerous condition called myelodysplastic syndrome (MDS), or low platelet count caused by any condition other than immune thrombocytopenia (ITP). Nplate® is only used if your low platelet count and medical condition increase your risk of bleeding. Nplate® is used to try to keep your platelet count about 50,000 per microliter in order to lower the risk for bleeding. Nplate® is not used to make your platelet count normal. It is not known if Nplate® works or if it is safe in people under the age of 1.

Please see Prescribing Information and Medication Guide for more information about Nplate® on Nplate.com.

References

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Important Safety Information

What is the most important information I should know about Nplate®?

  • Nplate® can cause serious side effects, including:

  • Worsening of a precancerous blood condition to a blood cancer (leukemia): Nplate® is not for use in people with a precancerous condition called myelodysplastic syndromes (MDS), or for any condition other than immune thrombocytopenia (ITP). If you have MDS and receive Nplate®, your MDS condition may worsen and become an acute leukemia. If MDS worsens to become acute leukemia you may die sooner from the acute leukemia.

  • Higher risk for blood clots:

    • You may have a higher risk of getting a blood clot if your platelet count becomes high during treatment with Nplate®. You may have severe complications or die from some forms of blood clots, such as clots that spread to the lungs or that cause heart attacks or strokes.